Abstract
Modification of the potent imidazole-based B-Raf inhibitor SB-590885 resulted in the identification of a series of furan-based derivatives with enhanced CNS penetration. One such compound, SB-699393 (17), was examined in vivo to challenge the hypothesis that selective B-Raf inhibitors may be of value in the treatment of stroke.
MeSH terms
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Animals
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Central Nervous System / drug effects*
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Furans / chemical synthesis*
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Furans / chemistry
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Furans / pharmacology*
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Imidazoles / chemistry
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Imidazoles / pharmacology
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Indans / chemical synthesis*
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Indans / chemistry
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Indans / pharmacology*
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Molecular Structure
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Proto-Oncogene Proteins B-raf / antagonists & inhibitors*
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Pyridines / chemistry
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Pyridines / pharmacology
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Rats
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Stroke / drug therapy
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Structure-Activity Relationship
Substances
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Furans
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Imidazoles
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Indans
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L-779,450
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Pyridines
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SB-590885
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SB-699393
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Proto-Oncogene Proteins B-raf